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Neuroendocrine Regulation of Growth Hormone Secretion.

Identifieur interne : 001A56 ( Main/Exploration ); précédent : 001A55; suivant : 001A57

Neuroendocrine Regulation of Growth Hormone Secretion.

Auteurs : Frederik J. Steyn [Australie] ; Virginie Tolle [France] ; Chen Chen [Australie] ; Jacques Epelbaum [Australie]

Source :

RBID : pubmed:27065166

Descripteurs français

English descriptors

Abstract

This article reviews the main findings that emerged in the intervening years since the previous volume on hormonal control of growth in the section on the endocrine system of the Handbook of Physiology concerning the intra- and extrahypothalamic neuronal networks connecting growth hormone releasing hormone (GHRH) and somatostatin hypophysiotropic neurons and the integration between regulators of food intake/metabolism and GH release. Among these findings, the discovery of ghrelin still raises many unanswered questions. One important event was the application of deconvolution analysis to the pulsatile patterns of GH secretion in different mammalian species, including Man, according to gender, hormonal environment and ageing. Concerning this last phenomenon, a great body of evidence now supports the role of an attenuation of the GHRH/GH/Insulin-like growth factor-1 (IGF-1) axis in the control of mammalian aging.

DOI: 10.1002/cphy.c150002
PubMed: 27065166


Affiliations:


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Le document en format XML

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